· by Glendon Lloyd Dip.Canine.Nutrition Dip.Dog.Nutrigenomics
Discover the Power of Quercetin for Your Dog
Quercetin is a powerful flavonoid found in many fruits and vegetables, known for its antioxidant and anti-inflammatory properties. This article explores its extensive benefits for canine health, including its impact on allergies, inflammation, cancer, cardiovascular health, and immune support. Detailed mechanisms of how quercetin works, appropriate dosages, and the best ways to incorporate it into your dog’s diet are discussed. The article also answers common questions about quercetin’s safety, efficacy, and potential interactions with other medications, providing a comprehensive guide for dog owners looking to enhance their pet’s health.
What drugs for dogs cannot be taken with quercetin?
Are there any contraindications for quercetin?
Why is Quercetin called ‘Nature’s Benadryl’?
What is Quercetin?
Quercetin is a naturally occurring flavonoid, a type of plant pigment, found abundantly in various fruits, vegetables, leaves, and grains. As an antioxidant, it helps neutralise free radicals, preventing cellular damage and reducing inflammation. Quercetin is also known for its ability to combat allergies by acting as a natural antihistamine, making it a valuable supplement for both humans and animals.
Sources of Quercetin
Quercetin is present in a wide range of foods. Some of the richest sources include:
Apples: Particularly in the skin, apples are a significant source of quercetin.
Berries: Blueberries, blackberries, and cranberries contain high levels of this flavonoid.
Citrus Fruits: Oranges, lemons, and limes also contribute to dietary quercetin.
Onions: Red onions, in particular, are known for their high quercetin content.
Leafy Greens: Kale, spinach, and other leafy vegetables are good sources.
Broccoli and Brussels Sprouts: These cruciferous vegetables are rich in quercetin.
Green Tea: A well-known source of antioxidants, including quercetin.
Red Wine: Made from grapes, red wine contains quercetin as well.
American elder; St. John’s wort; Ginkgo biloba: Good sources of the flavonoid
Parsley and Sage: Include many powerful antioxidants including quercetin
Capers: These edible flower buds have the highest natural concentration of quercetin of all food sources
The Origins of Medicinal Use of Quercetin
Although the name has only been used since 1857, and is derived from quercetum (oak forest), (1) the unintentional use of quercetin in medicine dates back to ancient times, where it was used in traditional remedies for its healing properties. Ancient Chinese and Ayurvedic medicine practitioners utilised quercetin-rich plants to treat a variety of ailments, including inflammation, allergies, and infections. Modern scientific research has since confirmed many of these uses, highlighting quercetin’s efficacy and broad therapeutic potential.
What Areas of Dog Health Does Quercetin Impact?
While little research has been done on the effects of quercetin for dogs, significant research has been done on other animals and humans. Given the translational nature of dog-human interactions clinically it is not unrealistic to extrapolate the health benefits of quercetin to our dogs.
Allergies and Itching
Quercetin is thought to be highly effective in managing allergies in dogs. It works by stabilising mast cells and preventing the release of histamines, the chemicals responsible for allergic reactions. This results in a reduction of symptoms such as itching, swelling, and redness. Dogs with seasonal allergies, food allergies, or environmental allergies that manifest in issues such as canine atopic dermatitis, can benefit significantly from quercetin supplementation. (2, 3, 4)
Inflammation
Quercetin’s anti-inflammatory properties make it beneficial for dogs with conditions like arthritis, inflammatory bowel disease (IBD), and other chronic inflammatory disorders. By inhibiting the production of inflammatory enzymes, quercetin helps reduce pain, swelling, and discomfort associated with these conditions. (4, 5, 6, 7)
Cancer
Research indicates that quercetin has anti-cancer properties. It can induce apoptosis (programmed cell death) in cancer cells and inhibit their growth and proliferation. While not a cure, quercetin can be a valuable adjunct therapy in the management of cancer in dogs, helping to slow the progression of the disease and improve quality of life. (8, 9, 10, 11)
Cardiovascular Health
Quercetin supports cardiovascular health by enhancing the function of blood vessels, reducing blood pressure, and improving overall circulation. Its antioxidant properties also protect the heart and blood vessels from oxidative damage, reducing the risk of cardiovascular diseases. (12, 13)
Immune Support
Quercetin can modulate the immune system, reducing overactive immune responses while supporting overall immune function. This makes it beneficial for dogs with autoimmune diseases or those recovering from illness, as it helps balance immune activity and promote healing. (14, 15)
What are The Mechanisms of Impact?
Anti-Histamine Effect
Quercetin blocks the release of histamines from mast cells, which are responsible for allergic reactions. By stabilising these cells, quercetin prevents the cascade of allergic symptoms such as itching, redness, and swelling, making it an effective natural remedy for allergies. (4)
Anti-Inflammatory Action
Quercetin inhibits key enzymes involved in the inflammatory process, such as cyclooxygenase (COX) and lipoxygenase (LOX). This reduces the production of pro-inflammatory mediators, thereby alleviating inflammation and associated pain. It is particularly useful for conditions like arthritis and inflammatory bowel disease.
Antioxidant Properties
As a potent antioxidant, quercetin neutralises free radicals, which are unstable molecules that can damage cells and contribute to aging and disease. By reducing oxidative stress, quercetin helps protect tissues and organs, supporting overall health and longevity. (16, 17, 18)
Anti-Cancer Mechanisms
Quercetin promotes apoptosis (programmed cell death) in cancer cells and inhibits pathways that lead to cancer cell growth and proliferation. It also reduces angiogenesis, the formation of new blood vessels that tumours need to grow. These mechanisms make quercetin a valuable supportive therapy in cancer treatment.
Cardiovascular Benefits
Quercetin improves endothelial function, which is essential for healthy blood vessels. It also lowers blood pressure and enhances circulation. Additionally, its antioxidant effects protect the cardiovascular system from oxidative damage, reducing the risk of heart disease and stroke.
Immune Modulation
Quercetin balances the immune system by reducing overactive immune responses while enhancing overall immune function. This dual action helps in managing autoimmune diseases and supporting recovery from infections or illnesses.
Quercetin Dosage for Dogs
The appropriate dosage of quercetin for dogs depends on their weight. Required human intake of quercetin is estimated to be between 5-40mg daily to enjoy the benefits. (1) Based on this a common guideline for dogs would be an uptake of 0.04-0.3 g of quercetin per kilogram of the dog’s body weight, given twice daily. For example, a 20-kilogram dog would typically require 1-6 mg of quercetin from natural sources twice a day. It is crucial to consult with a veterinarian to determine the correct dosage and to ensure it is safe for your specific dog, especially if they are taking other medications.
Best Ways to Include Quercetin in Dog’s Diet
Supplements
Quercetin supplements are available in various forms, including capsules, tablets, and powders. These supplements often contain bromelain, an enzyme that enhances the absorption and anti-inflammatory effects of quercetin. Giving these supplements with food can help improve digestion and absorption.
Natural Sources
Incorporating quercetin-rich foods into your dog’s diet is another effective way to provide this beneficial flavonoid. Adding small amounts of apples, berries, leafy greens, and broccoli to your dog’s meals can increase their quercetin intake. However, ensure these foods are safe for dogs and do not cause any digestive issues.
Homemade Treats
Homemade treats made with quercetin-rich ingredients can be a delicious way to supplement your dog’s diet. Recipes that include apples, blueberries, and spinach can provide a tasty and healthy treat that boosts your dog’s quercetin intake.
FAQ – Quercetin for Dogs
Is Quercetin good for dogs?
Yes, quercetin is beneficial for dogs. It offers antioxidant, anti-inflammatory, and anti-histamine properties that can help manage allergies, reduce inflammation, and support overall health.
Is Quercetin safe for dogs?
Quercetin is generally safe for dogs when given in the correct dosage. It is important to consult with a veterinarian before starting any new supplement to ensure safety and avoid potential interactions with other medications.
What Foods Contain Quercetin?
Foods rich in quercetin include apples, berries, citrus fruits, onions (do not feed onions to dogsas they are toxic), kale, spinach, broccoli, green tea, and red wine.
Does quercetin stop dog itching?
Yes, quercetin can help stop itching in dogs by reducing histamine release and alleviating allergic reactions. It acts as a natural antihistamine, making it effective for managing allergies.
Does quercetin fight inflammation in dogs?
Yes, quercetin fights inflammation by inhibiting pro-inflammatory enzymes and reducing oxidative stress. It is beneficial for conditions such as arthritis and inflammatory bowel disease.
Is quercetin with bromelain good for dogs?
Yes, individually both quercetin and bromelain offer dogs significant health benefits including antioxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, and anti-viral properties. (19,20). Combined with shiitake mushroom, the blend with quercetin and bromelain showed increased antioxidant capacity (21) which is known to reduce oxidative stress.
The appropriate dosage of quercetin for dogs depends on their weight. Required human intake of quercetin is estimated to be between 5-40mg daily to enjoy the benefits. (1) Based on this a common guideline for dogs would be an uptake of 0.04-0.3 g of quercetin per kilogram of the dog’s body weight, given twice daily. For example, a 20-kilogram dog would typically require 1-6 mg of quercetin from natural sources twice a day.
Can dogs have too much quercetin?
Yes, excessive amounts of quercetin can lead to side effects such as gastrointestinal upset, including nausea, vomiting, and diarrhoea. It is important to follow recommended dosages and consult with a veterinarian.
What drugs for dogs cannot be taken with quercetin?
Quercetin can interact with certain medications, including antibiotics, corticosteroids, and blood pressure medications. Always consult with a veterinarian before combining quercetin with other drugs to avoid potential interactions.
Are there any contraindications for quercetin?
Quercetin should be used with caution in dogs with kidney disease, as high doses can cause kidney damage. However quercetin has been shown to have a highly beneficial impact for humans with kidney disease. (19, 20, 21, 22) Consulting a veterinarian is essential before starting quercetin supplementation.
Why is Quercetin called ‘Nature’s Benadryl’?
Quercetin is often referred to as “Nature’s Benadryl” because of its potent antihistamine properties. Here’s a detailed explanation:
Histamine Blocking: Just like Benadryl (diphenhydramine), a well-known over-the-counter antihistamine used to treat allergies, quercetin blocks the release of histamines from mast cells. Histamines are chemicals in the body that trigger allergy symptoms such as pruritis, swelling, and redness. By preventing histamine release, quercetin helps reduce these allergic reactions effectively.
Anti-Inflammatory Effects: In addition to its antihistamine action, quercetin has strong anti-inflammatory properties. It inhibits the production of pro-inflammatory enzymes and cytokines, which can help alleviate symptoms of allergies and other inflammatory conditions. This dual action makes it similar to Benadryl, which also provides relief from allergy-induced inflammation.
Natural Alternative: Unlike Benadryl, which is a synthetic drug, quercetin is a naturally occurring flavonoid found in many fruits and vegetables. This natural origin appeals to those looking for holistic and plant-based alternatives to pharmaceutical medications.
Minimal Side Effects: Quercetin typically has fewer side effects compared to Benadryl. While Benadryl can cause drowsiness and other side effects, quercetin is generally well-tolerated when used in recommended dosages, making it a safer option for long-term use.
Versatility: Beyond its antihistamine and anti-inflammatory benefits, quercetin offers additional health benefits such as antioxidant protection, immune support, and cardiovascular health, further enhancing its reputation as a natural remedy.
Because of these properties, quercetin is considered a powerful natural alternative to Benadryl, offering similar benefits without the drawbacks of synthetic medications. This has earned it the nickname “Nature’s Benadryl” among holistic health enthusiasts and veterinarians.
Quercetin offers a range of formidable benefits for dogs, from alleviating allergies and inflammation to supporting cardiovascular health and fighting cancer. By understanding the correct dosage and best ways to include it in your dog’s diet, you can effectively leverage quercetin’s powerful properties to enhance your pet’s health and well-being.
About Glendon Lloyd Dip.Canine.Nutrition Dip.Dog.Nutrigenomics
I have had dogs from the day I was born. Much to my Mum's amusement, my Dad bought home Zetta, a beautiful corgi puppy on the day, as his contribution to our new family!
Fast forward to 2018 and Catherine, my wife, and one of our dogs Poppy, were both diagnosed and treated for cancer within months of each other
Diet and its impact on health, cancer particularly, led me down a rabbit hole of discovery.
I consumed information voraciously - on our diets, our dogs' diets and the impact these have not just on health but also the health of our increasingly fragile planet.
I was humbled by the time and expertise given so freely by doctors and vets, canine nutritionists and scientists, academics and agronomists. The more I learned the more I understood there had to be a better way to improve not just our health but also our dogs and the planet's.
The result of my trip down that rabbit hole is Bonza, a plant-based dog food that elevates our dogs' diet beyond simple nutrition to a diet that inspires a healthier everyday life for our dogs and the planet.
I am continually researching the nutritional impact our dogs' diets have on their health and wellbeing and the ingredients and nutrients we should include in, and exclude from, their food to deliver longer, healthier lives.
I am delighted that my trip down the rabbit hole has led to me completing a Diploma in Canine Nutrigenomics and a Diploma in Canine Nutrition being awarded a Distinction for both my coursework and theses!
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